Overview of the DIAGNOSE CTE Research Team

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Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease. Although the necessary risk factor for the development of this "tauopathy" is a history of repetitive head impacts, CTE itself should not be confused with traumatic brain injury or considered the cumulative effect of multiple concussions. It therefore cannot be studied with the same approaches and tools used to study brain trauma. Rather, to study the clinical presentation, diagnostic criteria, biomarkers, and risk factors of CTE requires expertise across many disciplines, including neurology, neuropsychology, psychiatry, neuroimaging, molecular medicine, neuropathology, exposure science, genetics, biostatistics, bioinformatics, engineering, and others. The success of this project will be facilitated by the multiple resources available across several sites. One of the primary resources is the superb group of approximately 50 co-investigators, consultants, and advisors working collaboratively on this study. A primary goal of this research program is to break down typical academic “silos” in order to conduct the best science in the most efficient manner. This project brings together a network of scientists and resources across major academic institutions and industry leaders, including:

The investigators and Advisory Board members for this project are leaders in most of the major collaborative studies of Alzheimer’s disease, as well as Traumatic Brain Injury, Post Traumatic Stress Disorder, Sports-Related Concussion, and Parkinson’s disease. In addition, many of the principle investigators and co-investigators already have extensive experience in the study of CTE, including NIH-funded projects that have led to important preliminary data to help guide the development of this project and, ultimately, to expedite the speed at which critical questions will be answered.